Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 12/20 | 0.57 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147461 | 0.83 | LIPE (0.57) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL18855867 | 0.83 | LIPE (0.53) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL20070188 | 0.82 | LIPE (0.56) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL29202405 | 0.82 | LIPE (0.56) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL16839482 | 0.82 | LIPE (0.52) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL30755072 | 0.82 | LIPE (0.52) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL5674167 | 0.81 | LIPE (0.62) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL20145199 | 0.81 | LIPE (0.55) | LIPELIPGEPHX2HSD11B1 | |
| SCHEMBL28377177 | 0.80 | LIPE (0.60) | LIPELIPGEPHX2HSD11B1SCN3A | |
| SCHEMBL7961541 | 0.80 | LIPG (0.53) | LIPELIPGEPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |