Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069757 | 0.86 | RET (0.43) | RETCCR3SLC6A9USP30P2RX7 | |
| SCHEMBL20147990 | 0.84 | RET (0.43) | RETCCR3USP30 | |
| SCHEMBL20147558 | 0.83 | P2RX7 (0.43) | RETCCR3SLC6A9USP30P2RX7 | |
| SCHEMBL20158497 | 0.83 | CCR3 (0.46) | RETCCR3SLC6A9P2RX7CACNA1H | |
| SCHEMBL20148057 | 0.77 | CCR3 (0.42) | RETCCR3SLC6A9USP30 | |
| SCHEMBL21651935 | 0.75 | RET (0.43) | RETCCR3USP30 | |
| SCHEMBL20626719 | 0.74 | RET (0.48) | RET | |
| SCHEMBL20069760 | 0.70 | RET (0.45) | RETCCR3USP30 | |
| SCHEMBL20069734 | 0.69 | RET (0.50) | RETCCR3P2RX7 | |
| SCHEMBL20068927 | 0.69 | CCR3 (0.45) | RETCCR3USP30P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | RET 1/4885CCR3 1128/4885SLC6A9 3553/4885 |
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | RET 1/4885CCR3 1128/4885SLC6A9 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.