Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919106 | 1.00 | HCRTR1 (0.43) | HCRTR1HCRTR2KLKB1CTSAHTR1A | |
| SCHEMBL2011408 | 0.91 | HCRTR1 (0.43) | HCRTR1HCRTR2KLKB1CTSAHTR1A | |
| SCHEMBL2051291 | 0.91 | HCRTR1 (0.43) | HCRTR1HCRTR2CTSAHTR1AHTR2A | |
| SCHEMBL2014592 | 0.91 | HCRTR1 (0.43) | HCRTR1HCRTR2CTSAHTR1AHTR2A | |
| SCHEMBL2012216 | 0.89 | EPHX2 (0.47) | HCRTR1HCRTR2KLKB1HTR1AHTR2A | |
| SCHEMBL2016502 | 0.85 | HCRTR1 (0.49) | HCRTR1HCRTR2KLKB1CTSAHTR1A | |
| SCHEMBL2052690 | 0.83 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2016348 | 0.83 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2012684 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2ALDH1A1HPGDNPC1 | |
| SCHEMBL2014058 | 0.81 | HCRTR1 (0.62) | HCRTR1HCRTR2KLKB1CTSAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |