Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148202 | 0.80 | GAA (0.33) | NPC1RAB9ASIGMAR1MAPTPOLB | |
| SCHEMBL20148209 | 0.77 | NPC1 (0.40) | KDM4ENPC1RAB9ASIGMAR1MAPT | |
| SCHEMBL20148200 | 0.77 | POLB (0.41) | MAPTPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL25308181 | 0.77 | TRIM24 (0.44) | KDM4ENPC1RAB9ATAAR1MAPT | |
| SCHEMBL1133951 | 0.77 | TRIM24 (0.48) | KDM4ETAAR1MAPTMAPK1POLB | |
| SCHEMBL16755649 | 0.76 | ALDH1A1 (0.53) | KDM4ENPC1RAB9AMAPTMAPK1 | |
| SCHEMBL1134095 | 0.75 | ALDH1A1 (0.50) | KDM4EMAPTPOLBHDAC6ALDH1A1 | |
| SCHEMBL17832213 | 0.75 | OGA (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL1133918 | 0.73 | POLB (0.57) | KDM4EMAPTMAPK1POLBHDAC6 | |
| SCHEMBL16654217 | 0.73 | TAAR1 (0.57) | KDM4ETAAR1TDP1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | RIPK2, RIPK1, RIPK4 | KDM4E 2958/4885NPC1 1981/4885RAB9A 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.