Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26241408 | 0.89 | NOS3 (0.45) | SMN1; SMN2HIF1AKCNH2ALDH1A1HRH4 | |
| SCHEMBL9024100 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2HIF1AALDH1A1TDP1POLB | |
| SCHEMBL6991110 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL3294816 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2HIF1ATDP1POLBAPEX1 | |
| SCHEMBL7274937 | 0.72 | NOS2 (0.54) | KCNH2ALDH1A1HRH4KDM4ETSHR | |
| SCHEMBL10046577 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TDP1KDM4E | |
| SCHEMBL2015524 | 0.72 | GRIN2D (0.44) | KCNH2ALDH1A1KDM4ETHRBASIC3 | |
| SCHEMBL10617507 | 0.72 | HSP90AB1 (0.60) | SMN1; SMN2HRH4KDM4EHSP90AB1 | |
| Hydrochloric Acid SCHEMBL10618220 | 0.70 | HSP90AB1 (0.58) | SMN1; SMN2HRH4KDM4EHSP90AB1 | |
| SCHEMBL7500196 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486544-B2 | Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) | GE HEALTHCARE AS (NO) | 2016-11-08 | — | — | US | disclosed |
| US-9486544-B2 | Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) | GE HEALTHCARE AS (NO) | 2016-11-08 | — | — | US | disclosed |
| US-9486544-B2 | Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI) | GE HEALTHCARE AS (NO) | 2016-11-08 | — | — | US | disclosed |
| EP-2512524-B1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2016-10-05 | — | — | EP | disclosed |
| EP-2512524-B1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2016-10-05 | — | — | EP | disclosed |
| EP-2512524-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE Healthcare AS (NO) | 2012-10-24 | — | — | EP | disclosed |
| US-20120244081-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2012-09-27 | — | — | US | disclosed |
| US-20120244081-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2012-09-27 | — | — | US | disclosed |
| US-20120244081-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2012-09-27 | — | — | US | disclosed |
| WO-2011073371-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073371-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | GE HEALTHCARE AS (NO) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120244081-A1 | MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) | MAG, MPI, MB | SMN1; SMN2 49/4885HIF1A 607/4885KCNH2 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.