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SCHEMBL20148710

SCHEMBL20148710

Cc1ccncc1C(=O)N1C2CC1CN(C(C)C)C2

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SIRT3 Q9NTG7 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ SMYD3 Q9H7B4 1/20 0.42
▸ RET P07949 1/20 0.40
▸ SOST Q9BQB4 1/20 0.35
▸ NAMPT P43490 2/20 0.35
▸ PIK3CD O00329 3/20 0.34
▸ GAA P10253 1/20 0.34
▸ CYP11B2 P19099 5/20 0.33
▸ CYP11B1 P15538 4/20 0.33
▸ HTR3A P46098 2/20 0.32
▸ GPBAR1 Q8TDU6 1/20 0.32
▸ GPR119 Q8TDV5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20069582 0.85 SIRT3 (0.46) SIRT3TDP1SMYD3RETSOST
SCHEMBL21159005 0.85 SMYD3 (0.39) SIRT3TDP1SMYD3RETSOST
SCHEMBL20148706 0.78 PIK3CD (0.54) TDP1PIK3CDGAA
SCHEMBL20148712 0.77 P2RX7 (0.40) TDP1RETGPR119
SCHEMBL20148704 0.74 PDE10A (0.44) RETPIK3CDGPR119
SCHEMBL20148700 0.74 VNN1 (0.37) RETPIK3CDGAA
SCHEMBL20148715 0.73 HCAR2 (0.43) SMYD3RETPIK3CDCYP11B2CYP11B1
SCHEMBL20148707 0.73 TDP1 (0.44) TDP1RET
SCHEMBL20148711 0.73 HDAC1 (0.40) RET
SCHEMBL20148714 0.72 PDE10A (0.43) RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-10172851-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-08 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF SIRT3 4404/4885TDP1 1003/4885SMYD3 1818/4885
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF SIRT3 4404/4885TDP1 1003/4885SMYD3 1818/4885
US-10172851-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, ROR1, BRAF SIRT3 4404/4885TDP1 1003/4885SMYD3 1818/4885
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF SIRT3 4404/4885TDP1 1003/4885SMYD3 1818/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF SIRT3 4404/4885TDP1 1003/4885SMYD3 1818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.