Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24126796 | 0.87 | BCHE (0.63) | CHRM2CHRM5CHRM1CHRM3BCHE | |
| SCHEMBL1865570 | 0.81 | RORC (0.49) | RORCNR1I2CHRM2CHRM5CHRM1 | |
| SCHEMBL22755777 | 0.80 | MEN1 (0.68) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL3598146 | 0.80 | MEN1 (0.68) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL6023725 | 0.80 | MEN1 (0.68) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL6902946 | 0.78 | MEN1 (0.74) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL20149132 | 0.77 | RORC (0.72) | RORCNR1I2CHRM2CHRM5CHRM1 | |
| SCHEMBL13974259 | 0.77 | RORC (0.70) | RORCNR1I2SIGMAR1 | |
| SCHEMBL20141240 | 0.77 | RORC (0.64) | RORCNR1I2CCR5 | |
| SCHEMBL25890035 | 0.76 | ACHE (0.60) | BCHEACHEBACE1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |