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SCHEMBL20149068

SCHEMBL20149068

CC(C)(C)OC(=O)N1C[C@@H](c2ccc(-c3c(F)cccc3F)cc2)[C@@](C)(c2ccc(F)c(C3CCC3)c2)C1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 20/20 0.51
▸ NR1I2 O75469 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20139613 0.85 RORC (0.69) RORC
SCHEMBL20139611 0.85 RORC (0.69) RORC
SCHEMBL20139689 0.75 RORC (0.72) RORCNR1I2
SCHEMBL20139633 0.75 RORC (0.72) RORCNR1I2
SCHEMBL20149072 0.74 RORC (0.50) RORC
SCHEMBL20149052 0.71 RORC (0.51) RORC
SCHEMBL20140441 0.71 RORC (0.80) RORC
SCHEMBL20139603 0.71 RORC (0.80) RORC
SCHEMBL25326718 0.70 GPR119 (0.48) RORC
SCHEMBL20139688 0.69 RORC (0.84) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089406-A1 ROR GAMMA MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 — — WO disclosed