SCHEMBL20149218

SCHEMBL20149218

IN1Cc2ccccc2/C=C\c2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 2/20 0.39
TSHR P16473 2/20 0.37
LMNA P02545 2/20 0.37
MAPK1 P28482 1/20 0.37
SCN4A P35499 1/20 0.37
SCN5A Q14524 1/20 0.37
SCN9A Q15858 1/20 0.37
P2RX4 Q99571 6/20 0.36
P2RX1 P51575 3/20 0.36
P2RX3 P56373 3/20 0.36
ALDH1A1 P00352 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PARP1 P09874 1/20 0.34
USP2 O75604 1/20 0.34
CDK4 P11802 1/20 0.34
ALOX15 P16050 1/20 0.34
CCND1 P24385 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19198881 0.76 HSD17B3 (0.42) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL22297598 0.76 LMNA (0.41) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL21308708 0.73 HSD17B3 (0.54) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL21251610 0.73 HSD17B3 (0.38) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL23255184 0.73 HSD17B3 (0.38) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL22295672 0.72 HSD17B3 (0.53) HSD17B3TSHRALDH1A1MEN1KMT2A
SCHEMBL19067688 0.72 HSD17B3 (0.39) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL19733706 0.72 P2RX4 (0.41) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL24455244 0.72 HSD17B3 (0.39) HSD17B3TSHRLMNAMAPK1SCN4A
SCHEMBL22601433 0.72 CHRM2 (0.40) HSD17B3TSHRLMNAMAPK1SCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183147-A1 CARRIER-PROTEIN POLYSACCHARIDE CONJUGATION METHODS VAXCYTE, INC. 2023-06-15 US disclosed
WO-2022270549-A1 NOVEL POLYMER-COATED CROSSLINKED ALGINATE GEL FIBER 持田製薬株式会社 2022-12-29 WO disclosed
WO-2022145419-A1 MULTILAYER STRUCTURE USING CHEMICALLY CROSSLINKED ALGINIC ACID 持田製薬株式会社 2022-07-07 WO disclosed
WO-2022136705-A1 GLYCAN-CONJUGATED ANTIBODIES BINDING TO FC-GAMMA RECEPTOR SYNAFFIX B.V. (NL) 2022-06-30 WO disclosed
WO-2022120476-A1 AMATOXIN ANALOGS AND USES THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2022-06-16 WO disclosed
EP-3991792-A1 TRANSPLANTATION DEVICE USING CHEMICALLY CROSSLINKED ALGINIC ACID Mochida Pharmaceutical Co., Ltd. (JP) 2022-05-04 EP disclosed
WO-2022040266-A1 CARRIER-PROTEIN POLYSACCHARIDE CONJUGATION METHODS VAXCYTE, INC. (US) 2022-02-24 WO disclosed
WO-2021125255-A1 NOVEL CROSSLINKED ALGINIC ACID 持田製薬株式会社 2021-06-24 WO disclosed
EP-3183345-B1 BIOCOMPATIBLE INFINITE COORDINATION POLYMER NANOPARTICLE-NUCLEIC ACID CONJUGATES FOR ANTISENSE GENE REGULATION UNIV NORTHWESTERN (US) 2021-06-16 EP disclosed
US-20210123057-A1 Sequence Multiplicity Within Spherical Nucleic Acids NORTHWESTERN UNIVERSITY 2021-04-29 US disclosed
EP-3812376-A1 PACLITAXEL-LIPID-POLYSACCHARIDE DUAL-TYPE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Santolecan Pharmaceuticals LLC (US) 2021-04-28 EP disclosed
WO-2021067439-A1 RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF THE JOHNS HOPKINS UNIVERSITY (US) 2021-04-08 WO disclosed
EP-3183007-B1 PROTEIN/OLIGONUCLEOTIDE CORE-SHELL NANOPARTICLE THERAPEUTICS UNIV NORTHWESTERN (US) 2020-06-17 EP disclosed
WO-2018089373-A9 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2018-07-12 WO disclosed
WO-2018089373-A2 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183147-A1 CARRIER-PROTEIN POLYSACCHARIDE CONJUGATION METHODS DDOST, STT3B, STT3A HSD17B3 3670/4885TSHR 3547/4885LMNA 2498/4885
US-20210123057-A1 Sequence Multiplicity Within Spherical Nucleic Acids TLR9, SRRT, MICA HSD17B3 4795/4885TSHR 1782/4885LMNA 3271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.