SCHEMBL2014946

SCHEMBL2014946

Cc1cccc(Cl)c1OC(Cl)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
POLB P06746 1/20 0.40
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
AKR1B1 P15121 1/20 0.38
PPARA Q07869 3/20 0.38
PPARG P37231 2/20 0.38
PTGS2 P35354 1/20 0.38
RARG P13631 1/20 0.36
RORC P51449 1/20 0.36
TSHR P16473 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
PTGER1 P34995 2/20 0.36
PTGER4 P35408 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9500663 0.83 TSHR (0.50) KMT2AL3MBTL1POLBALDH1A1KDM4E
SCHEMBL10359831 0.75 KDM4E (0.42) KMT2AL3MBTL1POLBKDM4ETSHR
SCHEMBL16572835 0.74 KDM4E (0.45) L3MBTL1KDM4ETSHRHTR2AHTR2B
SCHEMBL670029 0.74 KMT2A (0.38) KMT2APOLBAKR1B1PPARAPPARG
Acetic Acid SCHEMBL16005821 0.74 KMT2A (0.50) KMT2AL3MBTL1POLBALDH1A1KDM4E
SCHEMBL5053387 0.74 KMT2A (0.43) KMT2AL3MBTL1HPGDSMN1; SMN2PPARA
SCHEMBL900180 0.73 KDM4E (0.44) KMT2AL3MBTL1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL4534237 0.72 PPARA (0.47) KMT2AL3MBTL1POLBALDH1A1SMN1; SMN2
SCHEMBL9501805 0.72 KDM4E (0.61) KMT2AL3MBTL1POLBALDH1A1KDM4E
SCHEMBL9780698 0.72 KMT2A (0.49) KMT2AALDH1A1KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970504-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF Sage Therapeutics, Inc. (US) 2016-01-20 EP disclosed
EP-2958895-A1 THERAPEUTIC COMPOUNDS AND USES THEREOF Kala Pharmaceuticals, Inc. (US) 2015-12-30 EP disclosed
EP-2303888-B1 COMPOUNDS FOR ANTIMICROBIAL INTERVENTION HARVARD COLLEGE (US) 2015-05-06 EP disclosed
EP-2831079-A1 BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF Agency For Science, Technology And Research (SG) 2015-02-04 EP disclosed
WO-2014160441-A1 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF SAGE THERAPEUTICS, INC. (US) 2014-10-02 WO disclosed
WO-2014130612-A1 THERAPEUTIC COMPOUNDS AND USES THEREOF KALA PHARMACEUTICALS, INC. (US) 2014-08-28 WO disclosed
WO-2013147711-A1 BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-10-03 WO disclosed
EP-2512386-A1 A GASTROINTESTINAL IMPLANT DEVICE Vysera Biomedical Limited (IE) 2012-10-24 EP disclosed
WO-2011073970-A1 A GASTROINTESTINAL IMPLANT DEVICE VYSERA BIOMEDICAL LIMITED (IE) 2011-06-23 WO disclosed
US-6395745-B1 STABLE, CRYSTAL STRUCTURE; PLANT EXTRACT GLYCODESIGN, INC. (CA) 2002-05-28 US disclosed