Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.36 |
| ▸ | SMO | Q99835 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157296 | 1.00 | NOS3 (0.42) | NOS3NOS1NOS2KMT2APAX8 | |
| SCHEMBL5700487 | 0.83 | NOS3 (0.45) | NOS3NOS1NOS2KMT2APAX8 | |
| SCHEMBL30727252 | 0.78 | NFE2L2 (0.44) | KMT2AHSD11B1SLC40A1LMNANFE2L2 | |
| SCHEMBL27327132 | 0.78 | NFE2L2 (0.44) | KMT2ASLC40A1ALOX15HTTGLO1 | |
| SCHEMBL27327034 | 0.78 | NFE2L2 (0.44) | KMT2AHSD11B1SLC40A1LMNANFE2L2 | |
| SCHEMBL30727180 | 0.78 | NFE2L2 (0.44) | KMT2ASLC40A1ALOX15HTTGLO1 | |
| SCHEMBL1039344 | 0.78 | NOS3 (0.43) | NOS3NOS1NOS2KMT2APAX8 | |
| SCHEMBL3636398 | 0.78 | NOS3 (0.48) | NOS3NOS1NOS2KMT2APAX8 | |
| SCHEMBL4998230 | 0.78 | KDM4E (0.45) | NOS3NOS1NOS2KMT2APAX8 | |
| SCHEMBL31527719 | 0.76 | KMT2A (0.49) | NOS3NOS1NOS2KMT2APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |