Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133654 | 0.88 | MTOR (0.47) | MTORRPTORMLST8NAMPTADAM17 | |
| SCHEMBL20129668 | 0.84 | ADAM17 (0.39) | MTORRPTORMLST8ALDH1A1ADAM17 | |
| SCHEMBL22693220 | 0.82 | MTOR (0.46) | MTORRPTORMLST8ADAM17GRM5 | |
| SCHEMBL20129664 | 0.81 | ALDH1A1 (0.39) | MTORRPTORMLST8ALDH1A1ADAM17 | |
| SCHEMBL22693221 | 0.80 | MTOR (0.45) | MTORRPTORMLST8ALDH1A1GRM5 | |
| SCHEMBL20149780 | 0.80 | MTOR (0.48) | MTORRPTORMLST8ALDH1A1NAMPT | |
| SCHEMBL20157190 | 0.79 | GRM1 (0.47) | MTORRPTORMLST8ALDH1A1NAMPT | |
| SCHEMBL20149693 | 0.79 | MTOR (0.63) | MTORRPTORMLST8ALDH1A1NAMPT | |
| SCHEMBL20129674 | 0.78 | MTOR (0.51) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20149795 | 0.77 | MTOR (0.47) | MTORRPTORMLST8ALDH1A1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |