Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150167 | 0.78 | ALDH1A1 (0.46) | PKMSMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL20150171 | 0.76 | VCAM1 (0.60) | PKMSMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL26121327 | 0.75 | CYP19A1 (0.40) | PKMSMN1; SMN2KMT2AMEN1CYP19A1 | |
| SCHEMBL20150170 | 0.75 | ALDH1A1 (0.44) | PKMSMN1; SMN2KMT2AMEN1CYP19A1 | |
| SCHEMBL26117446 | 0.72 | MAPT (0.56) | SMN1; SMN2HPGDKMT2AMEN1CYP19A1 | |
| SCHEMBL29739941 | 0.72 | MAPT (0.56) | SMN1; SMN2HPGDKMT2AMEN1CYP19A1 | |
| SCHEMBL20225763 | 0.71 | TSHR (0.53) | PKMCYP19A1ALDH1A1MAPTKDM4E | |
| SCHEMBL29740109 | 0.70 | CYP19A1 (0.48) | CYP19A1ALDH1A1KDM4E | |
| SCHEMBL26116680 | 0.70 | CYP19A1 (0.48) | CYP19A1ALDH1A1KDM4E | |
| SCHEMBL23933066 | 0.68 | POLB (0.55) | KMT2AMEN1CYP19A1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | THRB 758/4885PKM 1134/4885SMN1; SMN2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.