Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205744 | 0.83 | MAPK1 (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL5205736 | 0.83 | MAPK1 (0.52) | ALDH1A1MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL5925578 | 0.82 | HSD17B2 (0.62) | ALDH1A1MAPTSMN1; SMN2PKMHPGD | |
| SCHEMBL25384692 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2PKMKMT2A | |
| SCHEMBL29750556 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2PKMKMT2A | |
| SCHEMBL6989419 | 0.78 | ALDH1A1 (0.59) | ALDH1A1MAPTSMN1; SMN2PKMKMT2A | |
| SCHEMBL20150169 | 0.78 | THRB (0.40) | ALDH1A1MAPTSMN1; SMN2PKMHPGD | |
| SCHEMBL2946181 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL15540054 | 0.76 | MAPT (0.46) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA | |
| SCHEMBL16961068 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | ALDH1A1 4827/4885MAPT 1236/4885SMN1; SMN2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.