Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.56 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015659 | 0.87 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2013001 | 0.82 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2011910 | 0.81 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2011292 | 0.79 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2054210 | 0.79 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2054212 | 0.79 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL13139060 | 0.79 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL13139102 | 0.79 | HCRTR1 (0.71) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2012839 | 0.78 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2017387 | 0.78 | HCRTR1 (0.71) | HCRTR1HCRTR2NPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |