Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19388495 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTHCAR2KMT2ASMN1; SMN2 | |
| SCHEMBL15114507 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTHCAR2KMT2ASMN1; SMN2 | |
| SCHEMBL29220153 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HCAR2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1273767 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HCAR2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL28507066 | 0.84 | ALDH1A1 (0.45) | ALDH1A1HCAR2KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL14847458 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HCAR2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL24425865 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HCAR2KMT2AMAPK1L3MBTL1 | |
| SCHEMBL29815474 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTHCAR2KMT2ASMN1; SMN2 | |
| SCHEMBL4005645 | 0.82 | ALDH1A1 (0.46) | ALDH1A1HCAR2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2032918 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MAPTHCAR2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134724-A1 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF | CURIA BUFFALO R&D, LLC | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134724-A1 | METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF | MAOB, MAOA, NISCH | ALDH1A1 418/4885MAPT 924/4885HCAR2 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.