Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.42 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248081 | 0.82 | RAPGEF4 (0.57) | RAPGEF4GAAALDH1A1HTTLMNA | |
| SCHEMBL10586957 | 0.80 | MAPT (0.39) | RAPGEF4GAAALDH1A1LMNAMEN1 | |
| SCHEMBL12368472 | 0.78 | RAPGEF4 (0.56) | RAPGEF4GAAALDH1A1HTTKDM4E | |
| SCHEMBL12883421 | 0.78 | PDK1 (0.49) | RAPGEF4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20620435 | 0.78 | MAPT (0.40) | GAAALDH1A1HTTKDM4ELMNA | |
| SCHEMBL19848688 | 0.78 | RAPGEF4 (0.39) | RAPGEF4GAAALDH1A1KDM4ELMNA | |
| SCHEMBL9750979 | 0.78 | ALDH1A1 (0.48) | RAPGEF4ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL12883486 | 0.78 | ALDH1A1 (0.41) | RAPGEF4ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL29196035 | 0.75 | RAPGEF4 (0.71) | RAPGEF4GAAALDH1A1HTTKDM4E | |
| SCHEMBL9224102 | 0.75 | GAA (0.65) | RAPGEF4GAAALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | DREXEL UNIVERSITY (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | RAD52, RAD50, MRE11 | RAPGEF4 1796/4885GAA 2866/4885ALDH1A1 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.