Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012708 | 0.88 | CCR1 (0.39) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2015837 | 0.88 | KDM4E (0.38) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2015005 | 0.88 | PIK3CD (0.44) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2011277 | 0.86 | CDC7 (0.37) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2014788 | 0.82 | TAAR1 (0.43) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2015833 | 0.77 | KDM4E (0.53) | KDM4EL3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3913880 | 0.75 | KCNA5 (0.40) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL2015215 | 0.74 | L3MBTL1 (0.44) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL10157048 | 0.74 | COMT (0.49) | KDM4EL3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2017434 | 0.74 | TAAR1 (0.40) | CDC7ROCK2MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |