Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | TDO2 | P48775 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157048 | 0.89 | COMT (0.49) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL737088 | 0.86 | KDM4E (0.50) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2014459 | 0.83 | CDK1 (0.62) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2013981 | 0.83 | HTT (0.46) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL739954 | 0.78 | L3MBTL1 (0.51) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2015218 | 0.77 | CDC7 (0.40) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL16207365 | 0.76 | KDM4E (0.62) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL2017535 | 0.74 | MAPT (0.41) | KDM4EL3MBTL1ALDH1A1MAPTMPI | |
| SCHEMBL2018360 | 0.73 | SLC40A1 (0.36) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9056804 | 0.73 | KDM4E (0.68) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |