Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016191 | 0.87 | EGLN1 (0.39) | EGLN1BBOX1FTOPADI4ERN1 | |
| SCHEMBL20777914 | 0.79 | EGLN1 (0.46) | EGLN1BBOX1FTOMAPTLMNA | |
| SCHEMBL13728550 | 0.73 | EGLN1 (0.42) | EGLN1BBOX1FTOKDM4EMEN1 | |
| SCHEMBL2011676 | 0.70 | KDM4E (0.41) | LMNACYP3A4MAPK1KDM4EALDH1A1 | |
| SCHEMBL10041250 | 0.70 | EGLN1 (0.71) | EGLN1BBOX1FTO | |
| SCHEMBL1536355 | 0.69 | EGLN1 (0.46) | EGLN1BBOX1FTOMAPTLMNA | |
| SCHEMBL8352528 | 0.69 | EGLN1 (0.46) | EGLN1BBOX1FTOMAPTLMNA | |
| SCHEMBL14842361 | 0.68 | TDP1 (0.52) | MAPTLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL2014951 | 0.68 | MEN1 (0.49) | PADI4MAPTLMNAKDM4EMEN1 | |
| SCHEMBL12335687 | 0.67 | EGLN1 (0.45) | EGLN1BBOX1FTOERN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |