Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017407 | 0.85 | ADORA2A (0.36) | ADORA2ALMNAHPGDGABRPGABRD | |
| SCHEMBL2015782 | 0.76 | NT5E (0.36) | KDM4EALDH1A1HTTXBP1MAPK1 | |
| SCHEMBL2011675 | 0.73 | TRPM8 (0.43) | KDM4EALDH1A1HTTXBP1MAPK1 | |
| SCHEMBL2015005 | 0.71 | PIK3CD (0.44) | KDM4EALDH1A1HTTMAPK1LMNA | |
| SCHEMBL2015311 | 0.70 | EGLN1 (0.46) | KDM4EALDH1A1HTTMAPK1LMNA | |
| SCHEMBL12125684 | 0.70 | TAAR1 (0.48) | ADORA2ALMNAHPGDGABRPGABRD | |
| SCHEMBL2016569 | 0.68 | NT5E (0.36) | KDM4EALDH1A1HTTXBP1MAPK1 | |
| SCHEMBL2015218 | 0.68 | CDC7 (0.40) | KDM4EALDH1A1LMNATDO2CDC7 | |
| SCHEMBL2012708 | 0.66 | CCR1 (0.39) | KDM4EHTTADORA2ACDC7ROCK2 | |
| SCHEMBL2015837 | 0.66 | KDM4E (0.38) | KDM4ECDC7ROCK2MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |