Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291895 | 0.83 | MEN1 (0.48) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL2014459 | 0.79 | CDK1 (0.62) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL13859311 | 0.74 | CYP1A2 (0.52) | KMT2AALDH1A1HPGDHTTATM | |
| SCHEMBL16671974 | 0.73 | KDM4E (0.54) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7918991 | 0.73 | MEN1 (0.53) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL9153917 | 0.72 | MAPT (0.49) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL2012510 | 0.71 | PTPN22 (0.48) | — | |
| SCHEMBL553501 | 0.71 | ALDH1A1 (0.59) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4619587 | 0.71 | HSD17B10 (0.39) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL2318046 | 0.71 | HSP90AA1 (0.49) | MEN1KMT2AALDH1A1HSP90AA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |