Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 7/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22297451 | 1.00 | AR (0.49) | ARMEN1GAAMAPTKMT2A | |
| SCHEMBL7722013 | 0.75 | AR (0.42) | ARGAAMAPTKMT2AALDH1A1 | |
| SCHEMBL22297755 | 0.74 | SRD5A1 (0.40) | NOS3NOS1NOS2PNMTRORC | |
| SCHEMBL22297464 | 0.74 | SRD5A1 (0.40) | NOS3NOS1NOS2PNMTRORC | |
| SCHEMBL20153507 | 0.74 | SRD5A1 (0.40) | NOS3NOS1NOS2PNMTRORC | |
| SCHEMBL20153523 | 0.74 | SRD5A1 (0.40) | NOS3NOS1NOS2PNMTRORC | |
| SCHEMBL20153589 | 0.74 | SRD5A1 (0.38) | ARNOS3NOS1NOS2PNMT | |
| SCHEMBL20153529 | 0.72 | RORC (0.41) | RORC | |
| SCHEMBL22297736 | 0.71 | RORC (0.37) | GAAMAPTKDM4EALDH1A1RORC | |
| SCHEMBL20153522 | 0.71 | RORC (0.37) | GAAMAPTKDM4EALDH1A1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541786-B1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2018089402-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |