SCHEMBL7722013

SCHEMBL7722013

Cc1ccc2c(c1)NCC1CCCC21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.42
NOS2 P35228 3/20 0.41
NOS3 P29474 2/20 0.41
NOS1 P29475 2/20 0.41
CHRNB2 P17787 1/20 0.37
CHRNA4 P43681 1/20 0.37
HTR2C P28335 3/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.34
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25413141 0.77 NOS3 (0.42) ARNOS2NOS3NOS1CHRNB2
SCHEMBL5661864 0.76 AR (0.40) ARNOS2NOS3NOS1HTR2C
SCHEMBL13438556 0.76 AR (0.40) ARNOS2NOS3NOS1HTR2C
SCHEMBL8266212 0.76 AR (0.40) ARNOS2NOS3NOS1HTR2C
SCHEMBL3600208 0.76 AR (0.40) ARNOS2NOS3NOS1HTR2C
SCHEMBL22297451 0.75 AR (0.49) ARNOS2NOS3NOS1CHRNB2
SCHEMBL20153520 0.75 AR (0.49) ARNOS2NOS3NOS1CHRNB2
SCHEMBL7252266 0.73 LMNA (0.41) ARNOS2NOS1KMT2AGAA
SCHEMBL12413 0.72 CA1 (0.45) ARCHRNB2CHRNA4HTR2CCYP1A2
SCHEMBL6642761 0.71 NOS3 (0.44) NOS2NOS3NOS1CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391887-B1 ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISORDERS SCHERING AKTIENGESELLSCHAFT (DE) 2002-05-21 US disclosed