Sugi Predict

Sugi Predict / Compounds / SCHEMBL2015373

SCHEMBL2015373

SCHEMBL2015373

CCOC(=O)C1C2CC(O)CC21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPM1B O75688 1/20 0.44
▸ PTPN1 P18031 1/20 0.44
▸ PPP1CC P36873 1/20 0.44
▸ CYP1A2 P05177 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ ALDH1A1 P00352 4/20 0.37
▸ LMNA P02545 2/20 0.37
▸ SLC6A4 P31645 1/20 0.36
▸ SLC6A3 Q01959 1/20 0.36
▸ MAPT P10636 3/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ GAA P10253 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ HSD11B1 P28845 1/20 0.35
▸ ALOX15 P16050 1/20 0.34
▸ MGAM O43451 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15116882 1.00 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL15106228 1.00 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL15125241 1.00 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL15106229 1.00 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL15416142 0.89 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL20147252 0.83 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL19388646 0.83 PPM1B (0.44) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL360031 0.82 PPM1B (0.47) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL34472262 0.82 PPM1B (0.47) PPM1BPTPN1PPP1CCCYP1A2TSHR
SCHEMBL31184507 0.82 PPM1B (0.47) PPM1BPTPN1PPP1CCCYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435057-B2 Triazole carboxylic acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2025-10-07 — — US disclosed
US-12384768-B2 Isoxazole carboxylic acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-12 — — US disclosed
CN-119613408-A Bicyclic ketone compounds and methods of use thereof 豪夫迈·罗氏有限公司 2025-03-14 — — CN disclosed
CN-110914271-B Bicyclic ketone compounds and methods of use thereof 豪夫迈·罗氏有限公司 2024-12-10 — — CN disclosed
EP-3986552-B1 ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2024-09-18 — — EP disclosed
US-20240300974-A1 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2024-09-12 — — US disclosed
CN-112574236-B RET inhibitor, pharmaceutical composition and application thereof 广东东阳光药业股份有限公司 2024-08-09 — — CN disclosed
EP-4397309-A2 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF F. Hoffmann-La Roche AG (CH) 2024-07-10 — — EP disclosed
EP-3652178-B1 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2024-01-24 — — EP disclosed
EP-3652178-B1 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2024-01-24 — — EP disclosed
US-20150152065-A1 TNF -Alpha Modulating Benzimidazoles UCB BIOPHARMA SPRL (BE) 2015-06-04 — — US disclosed
US-20150023913-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2015-01-22 — — US disclosed
US-20140243290-A1 Aminopyrimidines as SYK Inhibitors ALTMAN MICHAEL D (US) 2014-08-28 — — US disclosed
US-8759366-B2 Aminopyrimidines as SYK inhibitors MERCK SHARP & DOHME CORP. (US) 2014-06-24 — — US disclosed
US-8551984-B2 Aminopyrimidines as SYK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-10-08 — — US disclosed
US-20130183269-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-07-18 — — US disclosed
US-20120277192-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME LLC 2012-11-01 — — US disclosed
EP-2513098-A1 AMINOPYRIMIDINES AS SYK INHIBITORS Merck Sharp & Dohme Corp. (US) 2012-10-24 — — EP disclosed
US-20110245205-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME LLC 2011-10-06 — — US disclosed
WO-2011075515-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME CORP. (US) 2011-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150152065-A1 TNF -Alpha Modulating Benzimidazoles TNF, TNFRSF1A, NFKBIA PPM1B 539/4885PTPN1 3821/4885PPP1CC 3248/4885
US-20110245205-A1 AMINOPYRIMIDINES AS SYK INHIBITORS SYK, BTK, LCK PPM1B 238/4885PTPN1 80/4885PPP1CC 1041/4885
US-20130183269-A1 Hepatitis C Virus Inhibitors HAVCR2, MAVS, EIF2AK2 PPM1B 145/4885PTPN1 344/4885PPP1CC 290/4885
US-12435057-B2 Triazole carboxylic acids as LPA antagonists LPAR3, LPAR1, LPAR5 PPM1B 2527/4885PTPN1 1643/4885PPP1CC 2433/4885
US-20140243290-A1 Aminopyrimidines as SYK Inhibitors SYK, BTK, LCK PPM1B 238/4885PTPN1 80/4885PPP1CC 1041/4885
US-20150023913-A1 Hepatitis C Virus Inhibitors HAVCR2, MAVS, EIF2AK2 PPM1B 145/4885PTPN1 344/4885PPP1CC 290/4885
US-12384768-B2 Isoxazole carboxylic acids as LPA antagonists LPAR3, LPAR1, LPAR5 PPM1B 2462/4885PTPN1 1596/4885PPP1CC 1594/4885
US-20120277192-A1 AMINOPYRIMIDINES AS SYK INHIBITORS SYK, BTK, LCK PPM1B 238/4885PTPN1 80/4885PPP1CC 1041/4885
US-20240300974-A1 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF HSD17B7, CYP11B1, CYP11B2 PPM1B 4474/4885PTPN1 4701/4885PPP1CC 4138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.