Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.31 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154097 | 0.89 | GPR119 (0.39) | POLBUSP30GPR119 | |
| SCHEMBL20138947 | 0.87 | POLB (0.33) | POLBUSP30PARP1PARP2GPR119 | |
| SCHEMBL20154258 | 0.87 | POLB (0.33) | POLBUSP30PARP1PARP2GPR119 | |
| SCHEMBL20154098 | 0.83 | KIT (0.40) | POLBGPR119CNR1GBA1 | |
| SCHEMBL20143003 | 0.83 | POLB (0.34) | POLBPARP1PARP2GPR119CNR1 | |
| SCHEMBL20154093 | 0.78 | POLB (0.34) | POLBGPR119CNR1GBA1 | |
| SCHEMBL21531638 | 0.76 | PI4KB (0.34) | PARP1 | |
| SCHEMBL20138763 | 0.73 | — | — | |
| SCHEMBL20154071 | 0.73 | GPR119 (0.41) | POLBUSP30GPR119GBA1 | |
| SCHEMBL30234844 | 0.73 | GPR119 (0.41) | POLBUSP30GPR119GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |