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Sugi Predict / Compounds / SCHEMBL20154097

SCHEMBL20154097

SCHEMBL20154097

C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1nc(-c2scnc2Cl)[nH]c(=O)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 11/20 0.39
▸ SMARCA2 P51531 1/20 0.37
▸ SMARCA4 P51532 1/20 0.37
▸ PBRM1 Q86U86 1/20 0.37
▸ ABCB1 P08183 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ USP30 Q70CQ3 1/20 0.34
▸ SPR P35270 3/20 0.34
▸ SETD7 Q8WTS6 1/20 0.33
▸ ADAMTS5 Q9UNA0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20154258 0.89 POLB (0.33) GPR119POLBUSP30
SCHEMBL20138947 0.89 POLB (0.33) GPR119POLBUSP30
SCHEMBL20154091 0.89 POLB (0.33) GPR119POLBUSP30
SCHEMBL21531638 0.87 PI4KB (0.34) ADAMTS5
SCHEMBL20154098 0.86 KIT (0.40) GPR119POLB
SCHEMBL20143003 0.85 POLB (0.34) GPR119POLB
SCHEMBL30234844 0.84 GPR119 (0.41) GPR119SMARCA2SMARCA4PBRM1ABCB1
SCHEMBL20154071 0.84 GPR119 (0.41) GPR119SMARCA2SMARCA4PBRM1ABCB1
SCHEMBL23426258 0.80 GPR119 (0.42) GPR119SMARCA2SMARCA4PBRM1ABCB1
SCHEMBL20154093 0.80 POLB (0.34) GPR119POLBADAMTS5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11766434-B2 Pyrimidinone derivatives as CDC7 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-26 — — US disclosed
US-11766434-B2 Pyrimidinone derivatives as CDC7 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-26 — — US disclosed
US-11766434-B2 Pyrimidinone derivatives as CDC7 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-26 — — US disclosed
CN-110088100-B Pyrimidone derivatives as CDC7 inhibitors 癌症研究科技有限公司 2023-02-17 — — CN disclosed
US-20220079942-A1 PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2022-03-17 — — US disclosed
US-11020396-B2 Pyrimidinone derivatives as Cdc7 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-06-01 — — US disclosed
EP-3538523-B1 PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2021-05-19 — — EP disclosed
WO-2018087527-A1 PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11766434-B2 Pyrimidinone derivatives as CDC7 inhibitors CDC7, CDK7, CDK17 GPR119 4072/4885SMARCA2 3390/4885SMARCA4 3361/4885
US-20220079942-A1 PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS CDC7, CDK7, CDK17 GPR119 4072/4885SMARCA2 3390/4885SMARCA4 3361/4885
US-11020396-B2 Pyrimidinone derivatives as Cdc7 inhibitors CDC7, CDK7, CDK17 GPR119 4072/4885SMARCA2 3390/4885SMARCA4 3361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.