Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | RARB | P10826 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 15/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12959456 | 0.93 | RARB (0.59) | RARARARBCNR1PIM1PIM2 | |
| SCHEMBL2016042 | 0.85 | CKS1B (0.48) | RARARARBCNR1 | |
| SCHEMBL27973420 | 0.85 | RARA (0.47) | RARARARBCNR1PIM1PIM2 | |
| SCHEMBL27872046 | 0.84 | RARA (0.46) | RARARARBCNR1PIM1PIM2 | |
| SCHEMBL2039478 | 0.81 | HTR3E (0.46) | RARARARBPIM1PIM2 | |
| SCHEMBL2018037 | 0.79 | RARB (0.56) | RARARARBCNR1PIM1PIM2 | |
| SCHEMBL2015994 | 0.79 | RARA (0.50) | RARARARBCNR1RARG | |
| SCHEMBL12959457 | 0.79 | RARB (0.54) | RARARARBCNR1PIM1PIM2 | |
| SCHEMBL8514041 | 0.79 | RARB (0.46) | RARARARBPIM1PIM2RARG | |
| SCHEMBL2015316 | 0.78 | HTR1A (0.45) | RARARARBCNR1PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666489-B | Sphingosine kinase inhibitors | MERCK PATENT GMBH | 2014-07-23 | — | — | CN | disclosed |
| EP-2513057-A1 | SPHINGOSINE KINASE INHIBITORS | Merck Patent GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| CN-102666489-A | Sphingosine kinase inhibitors | MERCK PATENT GMBH | 2012-09-12 | — | — | CN | disclosed |
| WO-2011072791-A1 | SPHINGOSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |