Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154980 | 0.85 | IGF1R (0.57) | IGF1RSYKGPR119AURKAAURKB | |
| SCHEMBL20154906 | 0.78 | ALDH1A1 (0.51) | GPR119NSD2KDM1AEHMT2RCOR1 | |
| SCHEMBL20154982 | 0.78 | ALDH1A1 (0.49) | GPR119NSD2KDM1AEHMT2RCOR1 | |
| SCHEMBL4071068 | 0.78 | SYK (0.51) | IGF1RSYKAURKAAURKBCCNK | |
| SCHEMBL20154930 | 0.78 | IGF1R (0.51) | IGF1RSYKGPR119AURKAAURKB | |
| SCHEMBL6832459 | 0.76 | SYK (0.57) | IGF1RSYKGPR119AURKAAURKB | |
| SCHEMBL21299894 | 0.75 | SYK (0.42) | IGF1RMERTKSYKGPR119AURKA | |
| SCHEMBL11346537 | 0.75 | IGF1R (0.71) | IGF1R | |
| SCHEMBL4067722 | 0.74 | SYK (0.58) | IGF1RMERTKSYKGPR119AURKA | |
| SCHEMBL11932348 | 0.73 | IGF1R (0.54) | IGF1RSYKGPR119DNMT3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |