Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154910 | 0.85 | IGF1R (0.48) | IGF1RGPR119AURKAAURKBDNMT3A | |
| SCHEMBL11346537 | 0.83 | IGF1R (0.71) | IGF1R | |
| SCHEMBL4071068 | 0.79 | SYK (0.51) | IGF1RAURKAAURKBSYK | |
| SCHEMBL6832459 | 0.78 | SYK (0.57) | IGF1RGPR119AURKAAURKBALDH1A1 | |
| SCHEMBL11932348 | 0.78 | IGF1R (0.54) | IGF1RGPR119CNR1DNMT3AALDH1A1 | |
| SCHEMBL20154906 | 0.77 | ALDH1A1 (0.51) | GPR119CNR1ALDH1A1 | |
| SCHEMBL20154982 | 0.77 | ALDH1A1 (0.49) | GPR119CNR1ALDH1A1 | |
| SCHEMBL20154930 | 0.77 | IGF1R (0.51) | IGF1RGPR119AURKAAURKBALDH1A1 | |
| SCHEMBL24996918 | 0.77 | PAK1 (0.52) | IGF1RFGFR1KDRAURKBCNR1 | |
| SCHEMBL22055106 | 0.77 | BRD4 (0.51) | IGF1RCNR1DNMT3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |