Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154924 | 0.85 | CHEK1 (0.44) | CHEK1ALDH1A1JAK2JAK1GPR119 | |
| SCHEMBL4067722 | 0.83 | SYK (0.58) | IGF1RAURKAAURKBGPR119SYK | |
| SCHEMBL6832459 | 0.79 | SYK (0.57) | IGF1RAURKAAURKBALDH1A1GPR119 | |
| SCHEMBL20154910 | 0.78 | IGF1R (0.48) | IGF1RAURKAAURKBALDH1A1GPR119 | |
| SCHEMBL15974468 | 0.77 | GPR119 (0.52) | IGF1RALDH1A1JAK2GPR119SYK | |
| SCHEMBL20154980 | 0.77 | IGF1R (0.57) | IGF1RAURKAAURKBALDH1A1GPR119 | |
| SCHEMBL20154981 | 0.77 | CHEK1 (0.74) | IGF1RCHEK1 | |
| SCHEMBL20154906 | 0.77 | ALDH1A1 (0.51) | ALDH1A1JAK1GPR119NSD2NPC1 | |
| SCHEMBL20154982 | 0.77 | ALDH1A1 (0.49) | ALDH1A1JAK1GPR119NSD2NPC1 | |
| SCHEMBL3270728 | 0.76 | SYK (0.52) | IGF1RCHEK1GPR119SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| EP-3530656-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |