Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444983 | 0.89 | PKM (0.59) | PKMKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30307579 | 0.82 | PKM (0.56) | PKMKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL23388820 | 0.82 | ALDH1A1 (0.50) | KDM4EHPGDHSD17B10CUL4AMAPT | |
| SCHEMBL513372 | 0.82 | PKM (0.56) | PKMKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL29750502 | 0.82 | ALDH1A1 (0.50) | KDM4EHPGDHSD17B10CUL4AMAPT | |
| SCHEMBL7214442 | 0.82 | KDM4E (0.47) | KDM4EHPGDHSD17B10MAPTALDH1A1 | |
| SCHEMBL6382109 | 0.82 | PKM (0.53) | PKMKDM4ECUL4AMAPTSMN1; SMN2 | |
| SCHEMBL31316398 | 0.81 | PKM (0.55) | PKMKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL23887370 | 0.81 | PKM (0.55) | PKMKDM4EHPGDHSD17B10MAPT | |
| SCHEMBL1100780 | 0.81 | KDM4E (0.46) | KDM4EHPGDHSD17B10MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078136-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS INC (US) | 2026-03-19 | — | — | US | disclosed |
| US-20240368198-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS INC (US) | 2024-11-07 | — | — | US | disclosed |
| US-20240109922-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS INC (US) | 2024-04-04 | — | — | US | disclosed |
| US-11248010-B2 | Compounds, compositions, and methods for modulating CFTR | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| EP-3440057-B1 | SILICONE ATOMS CONTAINING IVACAFTOR ANALOGUES | PROTEOSTASIS THERAPEUTICS INC (US) | 2021-09-22 | — | — | EP | disclosed |
| US-20210061823-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS, INC. | 2021-03-04 | — | — | US | disclosed |
| US-10662207-B2 | Compounds, compositions, and methods for modulating CFTR | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190153000-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS, INC. | 2019-05-23 | — | — | US | disclosed |
| EP-3440057-A1 | SILICONE ATOMS CONTAINING IVACAFTOR ANALOGUES | Proteostasis Therapeutics, Inc. (US) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017177124-A1 | SILICONE ATOMS CONTAINING IVACAFTOR ANALOGUES | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20040005986-A1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-01-08 | — | — | US | disclosed |
| US-6482773-B1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-11-19 | — | — | US | disclosed |
| US-6348628-B1 | HYDRAZONE HERBICIDE INTERMEDIATES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-02-19 | — | — | US | disclosed |
| US-6090753-A | 2-(SUBSTITUTED PHENYL), 5-HALOALKYL-PYRIDAZIN-3-ONE DERIVATIVES AS HERBICIDES; CONTROLLING WEEDS, METHOD OF MAKING BY REACTING A HYDRAZONE DERIVATIVE WITH A SPECIFIED PHOSPHORUS COMPOUND | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2000-07-18 | — | — | US | disclosed |
| EP-0850227-A1 | PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997007104-A1 | PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-02-27 | — | — | WO | disclosed |
| US-4818276-A | Herbicidal 1-aryl-Δ2 -1,2,4-triazolin-5-ones | FMC CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0231176-A1 | HERBICIDAL 1-ARYL-$g(d)?2 -1,2,4-TRIAZOLIN-5-ONES | FMC Corporation (US) | 1987-08-12 | — | — | EP | disclosed |
| WO-1987000730-A1 | HERBICIDAL 1-ARYL-delta2-1,2,4-TRIAZOLIN-5-ONES | FMC CORPORATION (US) | 1987-02-12 | — | — | WO | disclosed |
| CN-85106905-A | Contain 1-aryl-Δ 2-1,2,4, weedicide of-triazoline-5-ketone and preparation method thereof | — | 1987-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109922-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
| US-20240368198-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
| US-11248010-B2 | Compounds, compositions, and methods for modulating CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
| US-20190153000-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
| US-20040005986-A1 | Pyridazin-3-one derivatives, their use, and intermediates for their production | Q6ZSR9, HDHD5, CBR3 | PKM 1238/4885KDM4E 1347/4885HPGD 393/4885 |
| US-20210061823-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
| US-20260078136-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | CFTR, SCNN1B, SCNN1A | PKM 1951/4885KDM4E 2582/4885HPGD 2634/4885 |
| US-10662207-B2 | Compounds, compositions, and methods for modulating CFTR | CFTR, SCNN1B, SCNN1G | PKM 2993/4885KDM4E 4572/4885HPGD 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.