Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.47 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923911 | 0.79 | NFKBIA (0.49) | KDM4EALDH1A1POLBNFKBIASMN1; SMN2 | |
| SCHEMBL28172844 | 0.79 | PARP1 (0.46) | KDM4EALDH1A1SMN1; SMN2PARP1NPC1 | |
| SCHEMBL17035383 | 0.78 | ACLY (0.48) | KDM4EALDH1A1HSD17B10SMN1; SMN2PARP1 | |
| SCHEMBL23858522 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL30251494 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL11804278 | 0.77 | NSD2 (0.58) | ALDH1A1CDC25BNPC1RAB9ATDP1 | |
| SCHEMBL28529190 | 0.76 | NFKBIA (0.50) | NFKBIANPC1RAB9ALMNAMAPT | |
| SCHEMBL29923237 | 0.75 | PARP1 (0.43) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL21723279 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL441572 | 0.73 | NFKBIA (0.52) | KDM4EALDH1A1POLBNFKBIASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-B1 | WDR5 INHIBITORS AND MODULATORS | UNIV VANDERBILT (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |