SCHEMBL2015567

SCHEMBL2015567

COC(=O)c1ccc(/C=C/N(C)C)nc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
POLB P06746 1/20 0.43
TUBB4A P04350 2/20 0.41
TUBB P07437 2/20 0.41
TUBA3C P0DPH7 2/20 0.41
TUBA1B P68363 2/20 0.41
TUBA4A P68366 2/20 0.41
TUBB4B P68371 2/20 0.41
TUBB3 Q13509 2/20 0.41
TUBB2A Q13885 2/20 0.41
TUBB8 Q3ZCM7 2/20 0.41
TUBA3E Q6PEY2 2/20 0.41
TUBA1A Q71U36 2/20 0.41
TUBA1C Q9BQE3 2/20 0.41
TUBB6 Q9BUF5 2/20 0.41
TUBB2B Q9BVA1 2/20 0.41
TUBB1 Q9H4B7 2/20 0.41
MAPT P10636 4/20 0.41
L3MBTL1 Q9Y468 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2015570 1.00 KMT2A (0.43) KMT2AMEN1POLBTUBB4ATUBB
SCHEMBL2011509 0.80 SMN1; SMN2 (0.43) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12630261 0.79 SMN1; SMN2 (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21538827 0.77 KDM4E (0.48) KMT2AMEN1TUBB4ATUBBTUBA3C
SCHEMBL2009082 0.77 KDM4E (0.48) KMT2AMEN1TUBB4ATUBBTUBA3C
SCHEMBL2009080 0.77 KDM4E (0.48) KMT2AMEN1TUBB4ATUBBTUBA3C
SCHEMBL22717309 0.73 SMN1; SMN2 (0.45) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21538807 0.73 SMN1; SMN2 (0.41) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL424747 0.73 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29450481 0.73 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250375432-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2025-12-11 US disclosed
EP-3759092-B1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2023-12-20 EP disclosed
CN-112004811-B Compounds that modulate AMPA receptor function 加的夫大学学院咨询有限公司 2023-09-22 CN disclosed
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2023-01-05 US disclosed
US-11298345-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2022-04-12 US disclosed
US-11298345-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2022-04-12 US disclosed
EP-3560923-B1 ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2021-05-05 EP disclosed
EP-3560923-B1 ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2021-05-05 EP disclosed
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2021-04-22 US disclosed
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2021-04-22 US disclosed
US-20140315794-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL LIMITED (US) 2014-10-23 US disclosed
US-20140315794-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL LIMITED (US) 2014-10-23 US disclosed
US-20140315794-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL LIMITED (US) 2014-10-23 US disclosed
US-8618126-B2 Antiparisitic dihydroazole compounds and compositions comprising same MERIAL LIMITED (US) 2013-12-31 US disclosed
EP-2513104-A1 ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME Merial Limited (US) 2012-10-24 EP disclosed
WO-2011075591-A1 ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL LIMITED (US) 2011-06-23 WO disclosed
WO-2011075591-A1 ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL LIMITED (US) 2011-06-23 WO disclosed
US-20110152312-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL, INC. 2011-06-23 US disclosed
US-20110152312-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL, INC. 2011-06-23 US disclosed
US-20110152312-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME MERIAL, INC. 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KMT2A 1550/4885MEN1 2874/4885POLB 2625/4885
US-20140315794-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME DDT, CYP1A1, CYP1A2 KMT2A 2254/4885MEN1 1953/4885POLB 3376/4885
US-20250375432-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KMT2A 1213/4885MEN1 3513/4885POLB 2703/4885
US-20110152312-A1 ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME DDT, CYP1A1, CYP1A2 KMT2A 2254/4885MEN1 1953/4885POLB 3376/4885
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A KMT2A 1550/4885MEN1 2874/4885POLB 2625/4885
US-11298345-B2 Compounds that modulates AMPA receptor function GRIN1, GRM1, GRIN2A KMT2A 1550/4885MEN1 2874/4885POLB 2625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.