Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21790489 | 0.88 | KMT2A (0.46) | TSHRLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL12777750 | 0.75 | KMT2A (0.54) | TSHRLMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL14141593 | 0.74 | LMNA (0.55) | TSHRLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL9554772 | 0.74 | CNR2 (0.46) | TSHRLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL8962083 | 0.71 | LMNA (0.58) | TSHRLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL8368156 | 0.71 | GAA (0.76) | LMNASMN1; SMN2MAPTKDM4ECYP3A4 | |
| SCHEMBL17817424 | 0.71 | GAA (0.76) | LMNASMN1; SMN2MAPTKDM4ECYP3A4 | |
| SCHEMBL21790806 | 0.70 | KIF11 (0.37) | LMNASMN1; SMN2MAPTTP53KMT2A | |
| SCHEMBL14338648 | 0.69 | KMT2A (0.61) | HTTSMN1; SMN2MAPTTP53KMT2A | |
| SCHEMBL14338647 | 0.69 | KMT2A (0.61) | HTTSMN1; SMN2MAPTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442817-B2 | Inhibitors of RAD52 recombination protein and methods using same | DREXEL UNIVERSITY (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | DREXEL UNIVERSITY (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134727-A1 | Inhibitors of RAD52 Recombination Protein and Methods Using Same | RAD52, RAD50, MRE11 | TSHR 4465/4885LMNA 2462/4885HTT 2986/4885 |
| US-10442817-B2 | Inhibitors of RAD52 recombination protein and methods using same | RAD52, RAD50, MRE11 | TSHR 4465/4885LMNA 2462/4885HTT 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.