Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 13/20 | 0.56 |
| ▸ | ARG2 | P78540 | 12/20 | 0.56 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10265381 | 0.91 | ARG1 (0.53) | ARG1ARG2GNAO1HRH3CHRM1 | |
| SCHEMBL12294008 | 0.89 | ARG1 (0.74) | ARG1ARG2 | |
| SCHEMBL894674 | 0.89 | ARG1 (0.74) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL895761 | 0.88 | ARG1 (0.72) | ARG1ARG2 | |
| SCHEMBL20156730 | 0.81 | KCNH2 (0.50) | ARG1ARG2 | |
| SCHEMBL10264827 | 0.79 | ARG1 (0.56) | ARG1ARG2HRH3CHRM1CHRM2 | |
| SCHEMBL10265285 | 0.77 | ARG1 (0.63) | ARG1ARG2 | |
| SCHEMBL12292758 | 0.77 | GNAO1 (0.44) | GNAO1GNAI3GNAI1HRH3CHRM1 | |
| SCHEMBL20156734 | 0.77 | ARG1 (0.62) | ARG1ARG2CHRM1CHRM2CHRM4 | |
| SCHEMBL895021 | 0.77 | ARG1 (0.77) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |