Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30911413 | 0.81 | NOS1 (0.39) | MAPTNOS1PDE3BPDE3APLK4 | |
| SCHEMBL19153804 | 0.76 | ALDH1A1 (0.44) | PDE3BPDE3AKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12480129 | 0.75 | MAPT (0.48) | MAPTNOS1PLK4CHEK1AURKA | |
| SCHEMBL18237557 | 0.74 | PDE3B (0.44) | PDE3BPDE3ABTKKDM4EHPGD | |
| SCHEMBL18237595 | 0.72 | MAPT (0.42) | MAPTNOS1PLK4CHEK1AURKA | |
| SCHEMBL13178567 | 0.72 | REN (0.43) | PDE3BPDE3AGRM4 | |
| SCHEMBL402053 | 0.71 | MAPT (0.48) | MAPTNOS1PLK4CHEK1AURKA | |
| SCHEMBL1154955 | 0.71 | NOS1 (0.42) | MAPTNOS1PLK4CHEK1AURKA | |
| SCHEMBL2366705 | 0.71 | NOS1 (0.52) | MAPTNOS1PDE3BPDE3APLK4 | |
| SCHEMBL12480398 | 0.71 | NOS1 (0.52) | MAPTNOS1PLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |