Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140508 | 0.88 | CHRM2 (0.43) | MTORRPTORMLST8P2RX7MAPT | |
| SCHEMBL20140506 | 0.88 | CHRM2 (0.43) | MTORRPTORMLST8P2RX7MAPT | |
| SCHEMBL20157107 | 0.86 | MTOR (0.52) | MTORRPTORMLST8P2RX7ALDH1A1 | |
| SCHEMBL20140571 | 0.83 | DRD4 (0.39) | MTORRPTORMLST8P2RX7LMNA | |
| SCHEMBL20141285 | 0.80 | KDM4E (0.40) | MTORRPTORMLST8P2RX7NAMPT | |
| SCHEMBL20157344 | 0.78 | MTOR (0.50) | MTORRPTORMLST8PARP1NAMPT | |
| SCHEMBL20140684 | 0.77 | MTOR (0.51) | MTORRPTORMLST8PARP1NAMPT | |
| SCHEMBL20156938 | 0.77 | MTOR (0.51) | MTORRPTORMLST8PARP1NAMPT | |
| SCHEMBL20141394 | 0.76 | MTOR (0.42) | MTORRPTORMLST8P2RX7 | |
| SCHEMBL20141393 | 0.76 | MTOR (0.42) | MTORRPTORMLST8P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |