Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157104 | 0.79 | HRH3 (0.47) | MAPTHRH3ALDH1A1KDM4EHTT | |
| SCHEMBL20157077 | 0.70 | TP53 (0.37) | ALDH1A1KDM4EMEN1HTTKMT2A | |
| SCHEMBL19018769 | 0.70 | HTR1A (0.33) | MAPTHRH3ALDH1A1POLBGPR55 | |
| SCHEMBL21094230 | 0.69 | KCNH2 (0.36) | MAPTALDH1A1THRBNPSR1 | |
| SCHEMBL20157180 | 0.69 | TAAR1 (0.44) | MAPTALOX15KDM4EMEN1THRB | |
| SCHEMBL20149895 | 0.68 | TAS1R3 (0.34) | — | |
| SCHEMBL18432743 | 0.67 | KDM4E (0.35) | ALDH1A1POLBKDM4EKMT2AL3MBTL1 | |
| SCHEMBL18432740 | 0.66 | NPSR1 (0.36) | ALDH1A1MCL1NPSR1 | |
| SCHEMBL19113576 | 0.66 | — | — | |
| SCHEMBL611373 | 0.66 | HRH3 (0.60) | MAPTHRH3CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |