Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157264 | 0.91 | TP53 (0.38) | TP53HPGDGABRA1GABRB2MLYCD | |
| SCHEMBL20156934 | 0.78 | HPGD (0.40) | TP53HPGDGABRA1GABRB2MLYCD | |
| SCHEMBL20157023 | 0.73 | TP53 (0.35) | TP53HPGDGABRA1GABRB2MLYCD | |
| SCHEMBL20156979 | 0.70 | CACNA1C (0.33) | HPGDPGK1PGK2NOS3NOS1 | |
| SCHEMBL20157006 | 0.70 | MAPT (0.33) | KDM4EALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL18432740 | 0.68 | NPSR1 (0.36) | GABRA1GABRB2PGK1PGK2ALDH1A1 | |
| SCHEMBL20231823 | 0.67 | PGK1 (0.50) | GABRA1GABRB2PGK1PGK2ALDH1A1 | |
| SCHEMBL8282807 | 0.67 | MLYCD (0.39) | TP53HPGDMLYCDALDH1A1LMNA | |
| SCHEMBL23252673 | 0.66 | HSP90AA1 (0.58) | HPGDGABRA1GABRB2MLYCDALDH1A1 | |
| SCHEMBL599112 | 0.65 | NOS3 (0.44) | GABRA1GABRB2PGK1PGK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |