Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746679 | 0.97 | TSHR (0.42) | TSHRAGTR1AGTR2HDAC6L3MBTL1 | |
| SCHEMBL20133582 | 0.93 | TSHR (0.42) | TSHRHDAC6ARCRHR1SMN1; SMN2 | |
| SCHEMBL8746684 | 0.90 | HDAC6 (0.41) | TSHRAGTR1AGTR2HDAC6L3MBTL1 | |
| SCHEMBL8773387 | 0.90 | HDAC6 (0.41) | TSHRAGTR1AGTR2HDAC6L3MBTL1 | |
| SCHEMBL21437153 | 0.79 | TDP1 (0.39) | TSHRALDH1A1HPGDNPSR1TDP1 | |
| SCHEMBL4932575 | 0.79 | UTS2R (0.36) | CRHR1MAPTHPGDNPSR1TDP1 | |
| SCHEMBL2560142 | 0.78 | TSHR (0.45) | TSHRHDAC6L3MBTL1MAPTALDH1A1 | |
| SCHEMBL7153352 | 0.78 | TDP1 (0.44) | CRHR1MAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL11166907 | 0.78 | HDAC6 (0.37) | TSHRAGTR1AGTR2HDAC6L3MBTL1 | |
| SCHEMBL21208571 | 0.75 | PKM (0.38) | ARCRHR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |