Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458573 | 0.88 | DYRK1A (0.45) | ADORA3PDE10ALMNAMEN1KMT2A | |
| SCHEMBL7154783 | 0.83 | AHR (0.43) | ADORA3PDE10AAHRADORA1CYP11B2 | |
| SCHEMBL19549714 | 0.81 | PDCD1 (0.46) | ADORA3PDE10ALMNANR1H2NR1H3 | |
| SCHEMBL15170804 | 0.78 | CYP11B2 (0.53) | ADORA3PDE10ANR1H2NR1H3NPC1 | |
| SCHEMBL18501188 | 0.77 | CYP11B2 (0.52) | LMNAKMT2ATDP1NPC1RAB9A | |
| SCHEMBL30601183 | 0.77 | CYP11B2 (0.51) | ADORA3PDE10ANR1H2NR1H3NPC1 | |
| SCHEMBL23486268 | 0.76 | MAPT (0.34) | PDE10AMEN1KMT2AAHRDHODH | |
| Hydrochloric Acid SCHEMBL23458449 | 0.75 | NAMPT (0.33) | PDE10ALMNAKMT2ANPSR1AHR | |
| SCHEMBL18764057 | 0.74 | TGFBR1 (0.49) | CYP11B2PARP1CYP11B1 | |
| SCHEMBL7708883 | 0.74 | PDE10A (0.56) | PDE10ALMNAMEN1USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |