Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11475282 | 0.79 | CYP11B2 (0.53) | PDE10AAHRNOTUMSMN1; SMN2NAMPT | |
| SCHEMBL9106396 | 0.78 | AHR (0.50) | PDE10AAHRDYRK1ACYP11B1CYP11B2 | |
| SCHEMBL19041650 | 0.77 | CYP11B2 (0.48) | PDE10AKDRAHRNOTUMLMNA | |
| SCHEMBL15173331 | 0.76 | PDE10A (0.53) | PDE10AAHRTDP2LMNASMN1; SMN2 | |
| SCHEMBL9104569 | 0.76 | PDE10A (0.54) | PDE10AAHRMEN1LMNAKMT2A | |
| SCHEMBL19167338 | 0.76 | PDE10A (0.60) | PDE10AAHRSMN1; SMN2NPC1MAPT | |
| SCHEMBL15173097 | 0.76 | PDE10A (0.53) | PDE10AAHRTDP2MEN1USP2 | |
| SCHEMBL9107248 | 0.76 | AHR (0.79) | PDE10AAHRNPC1RAB9ADHODH | |
| Hydrochloric Acid SCHEMBL16341275 | 0.75 | PDE10A (0.53) | PDE10AAHRMEN1LMNAKMT2A | |
| SCHEMBL20157092 | 0.74 | ADORA3 (0.47) | PDE10AAHRMEN1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |