Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141391 | 0.76 | MEN1 (0.35) | GRM5GRM1EEDRBBP4SUZ12 | |
| SCHEMBL20142115 | 0.75 | EED (0.48) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL24718042 | 0.75 | PDK4 (0.48) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL30798488 | 0.75 | PDK4 (0.48) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL15594974 | 0.75 | GRM5 (0.53) | GRM5GRM1PDK4NAMPT | |
| SCHEMBL3033965 | 0.74 | NAMPT (0.54) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL29826797 | 0.74 | HTT (0.50) | GRM5GRM1PDK4NAMPTNR1H2 | |
| SCHEMBL1764110 | 0.73 | PDK4 (0.49) | GRM5GRM1PDK4NAMPTJAK1 | |
| SCHEMBL29826188 | 0.73 | GRM5 (0.44) | GRM5GRM1PDK4NAMPTWNT3A | |
| SCHEMBL1763593 | 0.73 | PDK4 (0.47) | GRM5GRM1PDK4NAMPTJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |