Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 7/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139990 | 0.83 | MTOR (0.40) | GRM1MTORRPTORMLST8GRM5 | |
| SCHEMBL20139970 | 0.83 | GRM1 (0.39) | GRM1MTORRPTORMLST8GRM5 | |
| SCHEMBL20139868 | 0.78 | MTOR (0.52) | MTORRPTORMLST8GRM5DRD4 | |
| SCHEMBL30280978 | 0.73 | FASN (0.52) | DRD4 | |
| SCHEMBL20157245 | 0.73 | GRM1 (0.46) | GRM1GRM5ADAM17 | |
| SCHEMBL20139865 | 0.72 | P2RX7 (0.48) | MTORRPTORMLST8 | |
| SCHEMBL20140694 | 0.71 | MTOR (0.50) | MTORRPTORMLST8GRM5 | |
| SCHEMBL20139953 | 0.70 | CHRM2 (0.46) | GRM1MTORRPTORMLST8 | |
| SCHEMBL20156789 | 0.69 | MTOR (0.49) | GRM1MTORRPTORMLST8GRM5 | |
| SCHEMBL20140690 | 0.69 | GRM1 (0.43) | GRM1MTORRPTORMLST8DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |