Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157163 | 0.91 | MTOR (0.45) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20140569 | 0.84 | MTOR (0.51) | PARP1MTORRPTORMLST8HTR7 | |
| Trifluoroacetic Acid SCHEMBL20140610 | 0.79 | MTOR (0.49) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20140762 | 0.77 | HTR6 (0.47) | PARP1MTORRPTORMLST8DRD4 | |
| SCHEMBL20140726 | 0.76 | MAPK14 (0.55) | PARP1MTORRPTORMLST8TACR3 | |
| SCHEMBL20141863 | 0.75 | MTOR (0.53) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20140044 | 0.74 | MTOR (0.54) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20141431 | 0.74 | TACR3 (0.48) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20156786 | 0.73 | MTOR (0.51) | PARP1MTORRPTORMLST8HTR7 | |
| SCHEMBL20156931 | 0.70 | MTOR (0.51) | PARP1MTORRPTORMLST8HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |