Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 8/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157190 | 0.85 | GRM1 (0.47) | GRM1MTORRPTORMLST8NAMPT | |
| SCHEMBL20142672 | 0.85 | MTOR (0.50) | GRM1MTORRPTORMLST8NAMPT | |
| SCHEMBL20142669 | 0.85 | MTOR (0.50) | GRM1MTORRPTORMLST8NAMPT | |
| SCHEMBL20140684 | 0.84 | MTOR (0.51) | GRM1MTORRPTORMLST8NAMPT | |
| SCHEMBL20156938 | 0.84 | MTOR (0.51) | GRM1MTORRPTORMLST8NAMPT | |
| SCHEMBL20157143 | 0.81 | MTOR (0.45) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20141016 | 0.78 | MTOR (0.53) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20156949 | 0.76 | MTOR (0.54) | MTORRPTORMLST8NAMPTGRM5 | |
| SCHEMBL20140709 | 0.76 | GRM1 (0.50) | GRM1MTORRPTORMLST8MEN1 | |
| SCHEMBL20142060 | 0.76 | GRM1 (0.50) | GRM1MTORRPTORMLST8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |