Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 7/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16746099 | 0.74 | TNF (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL20314844 | 0.74 | TNF (0.37) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL22076299 | 0.73 | IMPDH2 (0.39) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL21178948 | 0.73 | TNF (0.53) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL30687262 | 0.73 | TNF (0.44) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL20314889 | 0.73 | TNF (0.53) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL29066876 | 0.72 | IMPDH2 (0.36) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL18876113 | 0.71 | MCL1 (0.43) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL29492540 | 0.70 | BRD4 (0.40) | IMPDH2IMPDH1BRD4TAF1BRPF1 | |
| SCHEMBL25596753 | 0.70 | NR3C1 (0.40) | IMPDH2IMPDH1BRD4TAF1BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |