Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.41 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157831 | 0.89 | CXCR2 (0.40) | LMNACXCR2LPLLIPGMAPT | |
| SCHEMBL20157410 | 0.86 | CXCR2 (0.39) | CXCR2LPLLIPGMAPTPRNP | |
| SCHEMBL21362596 | 0.83 | LPL (0.42) | LMNACXCR2LPLLIPG | |
| SCHEMBL20157558 | 0.83 | CXCR2 (0.37) | CXCR2LPLLIPGMAPTPRNP | |
| SCHEMBL21362081 | 0.82 | CXCR2 (0.38) | CXCR2LPLLIPGMAPTPRNP | |
| SCHEMBL20157420 | 0.82 | CXCR2 (0.36) | LMNACXCR2LPLLIPGMAPT | |
| SCHEMBL20157880 | 0.81 | CXCR2 (0.36) | LMNACXCR2LPLLIPGMAPT | |
| SCHEMBL21362027 | 0.81 | CXCR2 (0.35) | CXCR2LPLLIPGMAPTPRNP | |
| SCHEMBL20157904 | 0.81 | CXCR2 (0.35) | LMNACXCR2LPLLIPGMAPT | |
| SCHEMBL21362722 | 0.79 | CXCR2 (0.36) | LMNACXCR2LPLLIPGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |