Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 6/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362597 | 0.90 | LPL (0.43) | LPLLIPGPLK1CNR2RARB | |
| SCHEMBL21362722 | 0.84 | CXCR2 (0.36) | LPLLIPGCXCR2ALDH1A1LMNA | |
| SCHEMBL20157420 | 0.83 | CXCR2 (0.36) | LPLLIPGCXCR2ALDH1A1LMNA | |
| SCHEMBL20157831 | 0.83 | CXCR2 (0.40) | LPLLIPGCXCR2ALDH1A1LMNA | |
| SCHEMBL20157565 | 0.83 | LMNA (0.43) | LPLLIPGCXCR2LMNA | |
| SCHEMBL20157558 | 0.82 | CXCR2 (0.37) | LPLLIPGCXCR2 | |
| SCHEMBL20157904 | 0.82 | CXCR2 (0.35) | LPLLIPGCXCR2ALDH1A1LMNA | |
| SCHEMBL21362081 | 0.81 | CXCR2 (0.38) | LPLLIPGCXCR2 | |
| SCHEMBL20157880 | 0.81 | CXCR2 (0.36) | LPLLIPGCXCR2ALDH1A1LMNA | |
| SCHEMBL21362027 | 0.80 | CXCR2 (0.35) | LPLLIPGCXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |